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          • A multidisciplinary optimisation clinic for lung and colorectal cancer patients with complex needs
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          • Evaluating the function and effectiveness of the Peter Mac multidisciplinary PEG clinic and PEG credentialed dietitian role
          • Evaluation of the effectiveness of a nutrition assistant role in the multidisciplinary head and neck cancer clinic
          • Exploring current service delivery and nutritional needs of adolescents & young adults (AYA) with cancer
          • How do I do that again?
          • Identifying non-stem cell transplant chemotherapy regimens associated with high nutritional risk in patients with a haematological malignancy
          • Impact of nutritional intervention in the outpatient management of long-term survivors of haematological malignancy treated with stem cell transplantation (SCT)
          • Malnutrition in Victorian Cancer Services (MVCS) Program
          • The 20km divide: exploring nutritional inequities at satellite centres
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          • A prospective study of swallowing and voice outcomes after treatment for small-cell lung cancer
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          • Cancer malnutrition eLearning program
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          • Evaluate patient food service models to best support improving nutrition care project
          • Feeding everyone from hospital to home project
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          • Local health service projects
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          • Optimising the cancer nutrition path project
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          • A retrospective and prospective audit of the use of subcutaneous lignocaine infusions
          • A systematic review for palliative care clinical indicators for pain
          • Advance Care Planning (ACP) studies
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          • Audit of prevalence of incident pain during RT
          • CAncer tiSsue Collection After DEath (CASCADE) - Bereaved experience
          • European survey of oncology patients’ experience of breakthrough pain (Phase III)
          • Exploration of doctors' views about suffering
          • Melanoma Immunotherapy Project - Looking for Lazarus (palliative care project)
          • Palliative Care Clinical Studies Collaborative projects (paCCSC)
          • Palliative care consultations in patients with cancer in an Australian Cancer Comprehensive Centre
          • Phase IV RCT study to assess the safety and efficacy of methoxyflurane (Penthrox™)
          • Retrospective audit of continuous lignocaine for TCell Lymphoma
          • Social media in palliative care practice
          • The Stop Cancer PAIN trial - A guideline implementation
        • Pharmacy research
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        • Defining Nets And Info4Nets Online Platform
        • Enhancing Lifestyle Behaviors Endometrial Cancer Enable Pilot
        • Expect Exploration Patient Experience Communication Clinical Drug
        • Navigate: An online treatment decision aid for men diagnosed with prostate cancer and their partners
        • SCORE: Shared care of colorectal cancer survivors
        • SECOND ears: Development of an audio-recording app for patient consultations
        • SUPER: Solving Cancer of Unknown Primary
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    • Research Centres and Centres of Excellence
      • Centre of Excellence in Cellular Immunotherapy
        • About the Centre
        • Structure and People
        • Pilot Clinical Trial Development Program
        • Standard of Care in CAR-T cell Therapy
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      • The Barrie Dalgleish Centre for Myeloma and Related Blood Cancers
        • About the Barrie Dalgleish Centre
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      • ProsTIC
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      • Wilson Centre for Blood Cancer Genomics
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    • Industry and commercialisation
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    • Cohort studies
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      • BROCADE
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      • ISKS
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    • Translational Research Centres
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Spotlight on Implementation Science

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Written by: Super User
Category: News
Published: 07 March 2023
Hits: 105

Peter Mac and the VCCC Alliance will soon be launching the Implementation Science in Cancer program. We talk to Senior Research Lead – Implementation Science Associate Professor Stephanie Best on the field in general and what the program seeks to achieve.

Role: Senior Research Lead – Implementation Science. It's a dual appointment between Peter Mac and the VCCC Alliance.

Been at Peter Mac since: March 2022. However, I was here for a week and then I went back to the UK for a month, for my first post-lockdown family trip. So I've kind of really only been here for the last few weeks. I'm very, very new.

How would you describe implementation science for someone who's not familiar with the field?

I tend to describe implementation science or implementation research as the structured approach to getting evidence-based practice into routine clinical practice.

Anybody can implement something new, and that's great. But if we want to be looking at implementing more widely, and learning from our implementation experience, then we need some structures in place around it. So it's really about helping people with an implementation frame to support what it is that they're doing.

You can't really evaluate something if you just give it a little go. Whereas if you take the time and use those implementation frameworks and models that are available, then they can help you get your evidence into practice.

As a joint appointment at Peter Mac and the VCCC Alliance, I'm also thinking bigger picture. We don't just want great care in one place. We want great care across the whole of Victoria. So that's where my passion lies.

Does that mean by implementing in this more systematic way you can possibly take something that works at Peter Mac and look at how you adapt it to say a regional hospital in Bendigo or Ballarat, for example?

Absolutely, absolutely. And equally the other way around. If those regional hospitals are doing something excellent and have really succeeded in doing something, we can ask: "How have they managed to do that? What can we learn from that? And how can we look at implementing that in other places?"

We're launching our Implementation Science in Cancer program on May 30. From a big picture perspective, what is that seeking to achieve?

It's about raising the profile and people's awareness of what implementation science can offer for them. So how we can be working with clinical teams to help them with their implementation efforts.

Implementation research is a team effort. So it's very much about bringing the clinical and context expertise together with the implementation expertise, to then see evidence-based practice practiced more widely.

Sure, so you're not saying to people, you have to do a crash course in implementation science and learn all the models. You can supply that knowledge and then they can bring the context and you go forward from there?

Yes. And I have had the pleasure of working with all sorts of amazing clinicians et al., particularly over the last few years. We don't understand the exact detail of what goes on in every lab, but they've got all of that knowledge and that's why they're the experts in their fields. And I can work alongside them, and we can discuss what sort of research plan we might want to put in place.

What's your background been to this point in your career?

I have a very, very extensive clinical background, we won't say how many years. I practiced as a chartered physiotherapist internationally before this, but then I got very interested in how in clinical practice and managing services, we would have this evidence so we would know that something's the best way to do something, but it wouldn't necessarily happen. A PhD in implementation science soon followed.

I came out to Australia about five years ago, planning to stay for one year working with Australian Genomics and looking at the implementation of genomics in the Australian healthcare system. And clearly, I'm still here.

What is the specific role you'll be playing in the Implementation Science in Cancer program? Is it being that initial contact for people?

Yes, absolutely and we will be introducing an implementation science collaboration questionnaire soon. Obviously I won't be able to do everybody's implementation, but oftentimes, it's about talking with people, finding out what it is they want to know, what is it they want to be doing. So if I can act as that person for Peter Mac and the VCCC Alliance that would just be marvelous.

I think I'm so new to Peter Mac and the VCCC Alliance, I don't know who I don't know. I'll need to spend a lot of time really getting out there and meeting people. Clearly, I'm well aware of the high quality clinical work that goes on at Peter Mac and the VCCC Alliance, and I really want to be getting to know people on the ground who are delivering care.

And that's not just staff but also consumers. They are a key part of implementation. It's about looking quite widely at who the range of stakeholders may be.

How can consumers get involved in implementation science? What role do you see them playing?

Well they can play all sorts of different roles, it really depends on what it is that you're seeking to do. Sometimes it's starting off, and really understanding the experience that they are going through and spending the time to kind of go: "Oh, is it really like that? That's not quite the way I thought it was working."

And sometimes it's about having consumers in more of an advisory role. We could be setting up some clinical guidelines, for example. In situations like that, it's often very helpful to have a consumer on board, even if they don't understand the nitty gritty of some of the details. They can be very helpful at going: "Hang on a second, how is that actually going to work when the GP sees the patient?"

Or it might be that we're designing some implementation strategies we want to put in place. Consumers can be really helpful at coming in and going: "Hmmm, I'm not sure if that's going to work" or "Yeah, no, that sounds great" or "This might be more appealing if we framed it this way round". So a massive continuum of potential engagement with consumers.

What do you enjoy most about being an implementation scientist or researcher?

I think one of the things I really enjoy about the role is that I get to meet so many different people. I get to work across so many different projects and see such a range of fantastic clinical work that's going on. So if I had to choose one thing, I would say it's that opportunity to meet so many different people.

If I was then to sneak in a second one, I think it's I've been really, really lucky with the highly skilled clinicians and lab scientists that I've worked with. I come to a project with my implementation hat on and I'm usually thinking really differently to everybody else in the room. I quite enjoy bringing new things into the discussion, and looking at how we can progress what it is they're already doing.

What's something about implementation science that you wish people at Peter Mac knew and perhaps they don't?

The fact that it takes time and takes resources. I think sometimes people think things like implementation are something you can just sort of throw in there and it'll happen. Actually, you need to spend the time to get embedded and understand what's happening, and collect the data, and analyze the data, and look at what you're going to do with it. Testing it, putting it in place, evaluating it, changing it. It does take time.

Does that mean sometimes people don't maybe tell you early enough that they need your help?

There is that. And it's always great to be involved early on but I also don't mind coming in later on, because you can come in at all sorts of different places. I think it's more about setting expectations. There is no magic bullet, and we need to consider each case that we're looking at.

 

National Reconciliation Week at Peter Mac

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Written by: Super User
Category: News
Published: 07 March 2023
Hits: 403

National Reconciliation Week is recognised as an important cultural event across Australia, that celebrates and builds the respectful relationships between Aboriginal and Torres Strait islander peoples and other Australians. This year’s theme is Be Brave, Make Change.

Celebrated from the 27th of May to the 3rd of June, Reconciliation Week marks the dates of the 1967 referendum which removed discriminatory clauses from the Australian Constitution, and the historic Mabo decision which saw the Australian High Court recognise native title.

This week is an important time to learn about our shared histories cultures and achievements, while exploring how we can all contribute to achieving reconciliation in Australia.

A recent Peter Mac National Reconciliation Week Survey 2022 found:

  • 90% of staff consider NRW important
  • 40% of staff have a limited understanding or very limits understanding of reconciliation
  • 90% do not recall any reconciliation events at their local clinical level in the last 2 years
  • 59% do not know the core principles of Peter Mac’s Reconciliation Action Plan.

Peter Mac is committed to educating our staff and enhancing our culture - which values and acknowledges Aboriginal and Torres Strait Islander Peoples. We recognise that reconciliation is not only important for First Nations Peoples, but for all Australians.

We will  commemorating Reconciliation Week with Smoking Ceremonies on Friday, Monday and Wednesday. Opera singing on Wednesday in the ground floor amphitheatre and educational discussions on this week’s Peter Mac Live on Friday 3rd of June. See the website or Connect events page for more information.

Join us this week, as we celebrate reconciliation and what it means across our hospital.

New drug combination shows promise in treating acute myeloid leukaemia

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Written by: Super User
Category: News
Published: 07 March 2023
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Research led by Peter Mac has found a new combination therapy for acute myeloid leukaemia (AML) that shows greater potency in a preclinical study than either drug used alone.

AML is an aggressive type of blood cancer. When a patient has AML, immature abnormal white blood cells accumulate in the bone marrow, preventing the production of normal blood cells. In addition, these cancer cells are unable to fight infection themselves.

In one regularly occurring type of AML, one of the drivers of the disease is a specific type of genetic abnormality.

"A bit of the genome from one chromosome gets stuck on a bit of the genome from another chromosome – fusing two genes together to form a new gene that doesn't occur in nature," says Peter Mac's Professor Ricky Johnstone, co-senior author of the research.

As a result of that genetic fusion, genes that should be off are now switched on and vice versa – leading to the development of leukaemia.

Researchers have been looking at how to stop this from happening, as a way to develop new therapies against AML that are insensitive to conventional chemotherapy.

"In this study we used a drug called a histone deacetylase inhibitor that dampens the cell's dysregulated response and slows down the growth of the leukaemia cells," says Peter Mac's Dr Pilar Dominguez, the other senior author on the research.

"But it also had an additional effect that we weren't expecting."

The drug caused one type of immune cells to produce a molecule called interferon, which has been known for decades to also have anti leukemic effects. It is also available as an FDA-approved drug.

"Fortuitously, the histone deacetylase inhibitor was also telling the body to produce its own interferon," Professor Johnstone says.

"The interferon acts on the leukaemia cells and ultimately results in death of the cancer cells," Dr Dominguez says.

Based on these results, the researchers designed a potent combination drug therapy consisting of both a histone deacetylase inhibitor and interferon. This combination showed superior anti-leukaemia effects to those seen using either drug alone.

"We hope this can be translated into a new approach to treat AML," Dr Dominguez says.

This research was possible thanks to a multi-institutional collaboration between Peter Mac, The Alfred, Monash University, the QIMR-Berhofer Medical Research Institute, the Peter Doherty Institute, the Hudson Institute of Medical Research in Australia, the University of Düsseldorf in Germany, and the Princess Margaret Cancer Centre in Canada.

It's been published in the June print issue of Cancer Discovery.

Image: Treatment with a histone deacetylase inhibitor induces production of interferon by immune cells, which causes differentiation of leukaemia cells into normal blood cells and ultimately their death (differentiated cells are marked with an arrow).

Glass art sparkles at Peter Mac

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Written by: Super User
Category: News
Published: 07 March 2023
Hits: 300

Sun streams through the windows at Peter Mac and illuminates cabinets filled with beautiful contemporary glass art – the light bouncing off the vibrant rainbow colours. 

Andrea Comerford and Peter MacCallum Cancer Centre Foundation Philanthropy and Fundraising Director, Carl Young

The new exhibition was made possible by Andrea Comerford who sold candles for more than five years to raise funds through the Peter MacCallum Cancer Foundation and contribute to Peter Mac’s art collection. 

“The art at Peter Mac has provided so much solace and comfort to me throughout my time coming to the building and I wanted to contribute to that is some way,” Mrs Comerford says.

“The beauty of art has the power to bring happiness to people who are perhaps not feeling so good. The colours of glass are exciting….the sun coming in and reflecting off it is stunning.”

A glass collector since her teens, Andrea worked with one of her favourite studios, the renowned Gordon Glass Blowers in Red Hill, with a view to their creating a special collection for Peter Mac.

She then contacted Peter Mac’s Art Curator Svetlana Karovich who collaborated with the studio to select final pieces for the hospital collection.

“I would like to thank Andrea and everyone who supported her to bring this wonderful project to life,” Ms Karovich says.

“There is a timeless quality and enduring appeal in glass whose traditions and techniques have changed little over the centuries yet it remains one of the most exciting and dynamic artforms today.”

Artworks being installed by Eileen Gordon and Grant Donaldson from Gordon Glass Blowers in Red Hill
Artworks being installed by Eileen Gordon and Grant Donaldson from Gordon Glass Blowers in Red Hill

Glass display cases for the project were purchased with generous support from the Victorian Government through the Community Support Fund. 

To celebrate the installation of the display Mrs Comerford met with Ms Karovich and Peter MacCallum Cancer Centre FoundationPhilanthropy and Fundraising Director, Carl Young, where she saw the results of her fundraising efforts.

The collection is on display on level two at Peter Mac’s Parkville headquarters – next to outpatient pathology. 

Help us improve our website

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Written by: Super User
Category: News
Published: 07 March 2023
Hits: 215

Peter Mac is currently developing a brand new website and we'd love to hear from patients, carers, staff and referring doctors.

We want to ensure the new site provides the best possible experience for consumers, so we've developed a quick survey to find out about your experiences with the current website and how we can improve it.

The survey will only take a few minutes to complete and we greatly appreciate your assistance.

Click here to access the survey.   

  1. Clinical trials led by Peter Mac presented at prestigious international cancer conference
  2. Rib tickling opportunity for our patients, carers, staff and the public
  3. New blood test could spare thousands of colon cancer patients from unnecessary chemotherapy
  4. Queen's Birthday Honours for Dr David Speakman and Professor Clare Scott

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The Peter MacCallum Cancer Centre acknowledges the traditional owners of the land on which our five sites are located throughout Victoria. We recognise their strength and resilience and pay our respects to their Elders past and present.

 

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The Peter MacCallum Cancer Centre acknowledges the traditional owners of the land on which our five sites are located throughout Victoria. We recognise their strength and resilience and pay our respects to their Elders past and present.

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