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          • A multidisciplinary optimisation clinic for lung and colorectal cancer patients with complex needs
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          • Evaluating the function and effectiveness of the Peter Mac multidisciplinary PEG clinic and PEG credentialed dietitian role
          • Evaluation of the effectiveness of a nutrition assistant role in the multidisciplinary head and neck cancer clinic
          • Exploring current service delivery and nutritional needs of adolescents & young adults (AYA) with cancer
          • How do I do that again?
          • Identifying non-stem cell transplant chemotherapy regimens associated with high nutritional risk in patients with a haematological malignancy
          • Impact of nutritional intervention in the outpatient management of long-term survivors of haematological malignancy treated with stem cell transplantation (SCT)
          • Malnutrition in Victorian Cancer Services (MVCS) Program
          • The 20km divide: exploring nutritional inequities at satellite centres
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          • A prospective study of swallowing and voice outcomes after treatment for small-cell lung cancer
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          • Cancer malnutrition eLearning program
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          • Evaluate patient food service models to best support improving nutrition care project
          • Feeding everyone from hospital to home project
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          • Local health service projects
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          • Optimising the cancer nutrition path project
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          • A retrospective and prospective audit of the use of subcutaneous lignocaine infusions
          • A systematic review for palliative care clinical indicators for pain
          • Advance Care Planning (ACP) studies
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          • Audit of prevalence of incident pain during RT
          • CAncer tiSsue Collection After DEath (CASCADE) - Bereaved experience
          • European survey of oncology patients’ experience of breakthrough pain (Phase III)
          • Exploration of doctors' views about suffering
          • Melanoma Immunotherapy Project - Looking for Lazarus (palliative care project)
          • Palliative Care Clinical Studies Collaborative projects (paCCSC)
          • Palliative care consultations in patients with cancer in an Australian Cancer Comprehensive Centre
          • Phase IV RCT study to assess the safety and efficacy of methoxyflurane (Penthrox™)
          • Retrospective audit of continuous lignocaine for TCell Lymphoma
          • Social media in palliative care practice
          • The Stop Cancer PAIN trial - A guideline implementation
        • Pharmacy research
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        • Defining Nets And Info4Nets Online Platform
        • Enhancing Lifestyle Behaviors Endometrial Cancer Enable Pilot
        • Expect Exploration Patient Experience Communication Clinical Drug
        • Navigate: An online treatment decision aid for men diagnosed with prostate cancer and their partners
        • SCORE: Shared care of colorectal cancer survivors
        • SECOND ears: Development of an audio-recording app for patient consultations
        • SUPER: Solving Cancer of Unknown Primary
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    • Research Centres and Centres of Excellence
      • Centre of Excellence in Cellular Immunotherapy
        • About the Centre
        • Structure and People
        • Pilot Clinical Trial Development Program
        • Standard of Care in CAR-T cell Therapy
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      • The Barrie Dalgleish Centre for Myeloma and Related Blood Cancers
        • About the Barrie Dalgleish Centre
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      • ProsTIC
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      • Wilson Centre for Blood Cancer Genomics
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    • Industry and commercialisation
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    • Cohort studies
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      • BROCADE
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      • ISKS
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    • Translational Research Centres
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  1. Home
  2. Blog

Positives on the horizon for lung cancer

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Written by: Super User
Category: News
Published: 07 March 2023
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Australia’s lung cancer statistics read like bad news but, thankfully, they are only half of the story.

Despite being the fifth most common cancer (behind prostate, breast, melanoma and bowel cancer in that order), lung cancer remains Australia’s No.1 cause of cancer deaths.

Another 8,664 Australians lives will be lost to lung cancer this year, well above the next placed bowel cancer (5,326 deaths) and pancreatic cancer (3,531 deaths).

The other, more positive half of the story is that after decades in which lung cancer’s long-term survival rate seemed stuck around 10% finally there are signs of progress.

While still at the back of the pack (e.g. prostate cancer’s five-year relative survival rate is 96%), five-year survival for lung cancer improved to 22% over the past decade and further gains are expected.

Peter Mac’s Professor Ben Solomon - who treats lung cancer patients and heads a lab advancing novel therapies - points to an expanding array of new, targeted drugs that are coming online.

“These targeted drugs, which have become standard-of-care relatively recently or are advancing through clinical trials, work in patients with specific molecular subsets of lung cancer,” says Prof Solomon. 

“There are still many questions as to how these drugs together with new immunotherapy treatments can best be used alongside or replace our conventional chemotherapy, radiotherapy and surgery.

“But the next generation of lung cancer treatment is here now and giving us hope of better outcomes for these patients, and further gains in long-term survival, into the future.”

View a list of some of these new drugs, and their targets.

In late October this year, Prof Solomon discussed results of a clinical trial of the targeted drug repotrectinib at a major Molecular Targets and Cancer Therapeutics conference in Barcelona.

The trial involved patients with non-small cell lung cancer and who were ROS1-positive, indicating they carried a gene fault that promotes uncontrolled cell growth.

Among patients not previously been treated with a similar drug (and so may be resistant), 79% showed a positive response to repotrectinib. 

Importantly, there were also signs the drug was active in lung cancers that had spread to the brain - a group for whom there are few effective treatment options.

Prof Solomon is also co-lead of the ASPiRATION trial which is providing comprehensive genomic testing to 1,000 newly diagnosed patients with lung cancer across Australia.

This identifies if a patient has any of a wide array of genetic targets (including ROS1 but many others) for which a targeted drug may be available, or in clinical trials.

This enables patients who are not responding well to conventional treatments to be diverted to drugs more likely to work for them, an approach known as “precision medicine”.

“Increasingly we see that understanding the genetic drivers of lung cancer in each patient is the key to improving outcomes,” Prof Solomon says.

“Targeted drugs, while not yet a cure, are extending life and improving quality of life for people with lung cancer and we’re starting to see the benefits in terms of improved long-term survival.”

November is Lung Cancer Awareness Month.

Find out more about Lung Cancer Awareness Month and how to spot the symptoms

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Wellbeing Centre Holiday Hours 2022

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Written by: Super User
Category: News
Published: 07 March 2023
Hits: 99

During the Christmas/New Year break, the Wellbeing Centre will be closed on all public holidays, with reduced hours on other days as follows:

  • Thursday 15th December - closing 1pm
  • Friday 23rd December - OPEN (9am - 1pm)
  • Monday 26th December - CLOSED
  • Tuesday 27th December - CLOSED
  • Wednesday 28th December - OPEN (9am - 4pm)
  • Thursday 29th December - OPEN (9am - 4pm)
  • Friday 30th December - OPEN (9am - 3pm)
  • Monday 2nd January - CLOSED

Normal hours will resume from Tuesday 3rd January, 9:00am - 5:00pm.  We will be also closed on Australia Day (Thursday, 26 January 2023).

From all the team in the Wellbeing Centre, we wish all our patients, carers and colleagues a very merry Christmas and a safe and happy New Year!

 

Celebrating Peter Mac volunteers

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Written by: Super User
Category: News
Published: 07 March 2023
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On International Volunteers Day, we thank our volunteers for their many contributions.

Peter Mac volunteers Aileen and Nishtha

Volunteers fulfil an integral role across many areas of Peter Mac. Each day, patients and carers access services designed to ease their cancer journey and make their hospital stay more comfortable.

Our volunteers provide a huge range of support services.

In the first half of 2022 they fitted 86 wigs for patients experiencing hair loss, and delivered 838 product bags to inpatients. They sewed 176 breast pillows, 370 hand-crafted bags, and 503 pieces of headwear.

Volunteers manage the Peter Mac Auxiliary Group, running a shop of handcrafted items that has been raising funds for nearly 40 years, and providing items direct to patients to improve their care and experience. 

Many volunteers also contribute to the Nancy Kinsella Patients’ Library, offering a wide variety of items from books to puzzles, for the enjoyment of both inpatients and outpatients. 

Speaking to volunteers Heather, Clarel, and Astrid, it’s clear that they love their work.

“If I can make someone smile I’m a very happy woman - if I can make them laugh I’m even happier. If somebody needs something I’m happy to do it,” says Heather, who has worked as a volunteer for four years.

“It’s rewarding for me as a person, and fulfilling. What I give out I get back in spades,” she says. 

Peter Mac’s volunteers create and maintain comfortable spaces like the Wellbeing Centre or Patient Library, which have a welcoming and inviting atmosphere than a ward or treatment room.

“It’s totally different there,” Astrid says, “you make people tea and coffee and just speak with them. You soon learn how to approach people and be sensitive to their needs and how they’re feeling”.

While some of the team have been directly affected by cancer and hope to pass on the care and support they received, others are here because they want “to do something worthwhile”, as Heather puts it.

Clarel explained that the strength of the team is invaluable.

“The best part about [the team] is the environment - the support, the atmosphere of validation that you get out from being here.”

Peter Mac’s volunteer service is newly reinvigorated following the pandemic, with volunteers clearly happy to be back on-site.

Peter Mac thanks every amazing volunteer and the staff that support them for their work, care, and dedication.

Click this link to learn more about volunteering at Peter Mac.

 

Peter Mac Researchers Present at Prestigious International Meeting

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Written by: Super User
Category: News
Published: 07 March 2023
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Experts from Peter Mac presented more than 50 pieces of research at the 64th annual American Society of Hematology conference in New Orleans over the weekend.

“The American Society of Hematology (ASH) is the preeminent haematology conference in the world bringing together more than 20,000 clinicians and scientists to help improve our understanding of, and outcomes for patients affected by, blood diseases,” Professor John Seymour, Director of Haematology at Peter Mac and Royal Melbourne Hospital, said.

“In 2022, more than 50 presentations of research projects conducted by Peter Mac were showcased at this international meeting! This is a true testament to the calibre of our clinicians and researchers and the Haematology program overall.”

We share with you three of the impressive research projects presented by Peter Mac at this year’s ASH conference.

Uncovering what causes a rare haematology condition

Associate Professor Piers Blombery, Professor Graham Lieschke and their collaborators have identified a rare genetic cause of a haematology condition that causes high blood counts and early onset autoimmune disease.

A local patient that was being treated for their lifelong high white blood cell and platelet count coupled with many autoimmune diseases was analysed by the diagnostic molecular service at Peter Mac. This revealed that the patient had a mutation in a gene called SH2B3.

Piers and Graham teamed up with collaborators in the UK who had identified another patient with a similar syndrome. It was found that this patient also had a mutated SH2B3 gene. To demonstrate that the mutated SH2B3 gene was causing the disease, Graham’s team genetically altered zebrafish to carry the SH2B3 mutation. These gene-edited zebrafish developed similar blood count abnormalities as the two patients.

Based on an understanding of how the SH2B3 gene normally regulates blood cell production, these fish were used to test a potential drug treatment for the disease. The treatment worked effectively to normalise their elevated blood counts.

Piers, Graham and their collaborators have combined clinical and laboratory work to successfully identify the gene responsible for this very rare disease, find a potential treatment to help with the condition, and a way to identify future patients when they present with similar symptoms.

An effective combination treatment for relapsed or refractory mantle cell lymphoma

People with a rare form of B-cell lymphoma known as mantle cell lymphoma are incredibly difficult to treat when their cancer returns or doesn’t respond to treatment. This is especially true for mantle cell lymphoma patients that carry a mutated TP53 gene.

Dr Adrian Minson and Associate Professor Michael Dickinson initiated and led a trial to test a combination of two treatments, ibrutinib which works to stop the cancer growth and tisagenlecleucel, a CD19 CAR T-cell therapy that uses the patient’s own genetically modified T-cells to seek out and destroy cancer.

The combination treatment was very effective with 80 per cent of patients having no lymphoma at four months. Patients were followed for an average of 13 months and the majority were still in remission at twelve months.

Impressively a proportion of the patients had genetic mutations that put them at a high risk of relapse with other treatments. These patients did very well on the combination providing an effective treatment for those at greatest risk of relapse.

The combination treatment only needs to be taken for a short period of time, with tisagenlecleucel given as a single dose and ibrutinib given for approximately 6 months. Despite this, the treatment was effective at keeping the lymphoma in remission.

Reducing the risk of severe COVID-19 infections in our vulnerable cancer patients

Haematology nurse, Ashley Whitechurch, presented her research into the effectiveness of a treatment to prevent COVID-19 infections.

The pandemic left people with a blood cancer called chronic lymphocytic leukaemia (CLL) at risk of a severe COVID-19 infection because their cancer made the vaccination less effective.

To better protect these patients Peter Mac and Alfred Health ran a program to provide CLL patients with a COVID-19 preventative medication called Evusheld. A follow-on study was conducted to assess the effectiveness of this medication.

The preventative treatment was offered to 571 patients with 63 per cent of people taking up the offer. Only eight of the 236 patients in ongoing follow up were diagnosed with COVID-19 within 3 months of receiving Evusheld.

Overall, Evusheld was well tolerated with early rates of severe COVID-19 infection post administration appearing low.

Potent results from new immune treatment in patients with hard-to-treat blood cancers

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Written by: Super User
Category: News
Published: 07 March 2023
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A new drug is showing potent results in hard-to-treat blood cancers and was able to trigger a complete response – meaning the cancer became undetectable – for more than a third of patients.

All patients in the Phase I / II clinical trial of glofitamab had Diffuse Large B-Cell Lymphoma (DLBCL) and their cancer had relapsed or was no longer responding to conventional treatments, including CAR T-cell therapy.

Peter Mac treated the first patients in the world with glofitamab and was a major recruitment site for this international and multi-centre study of 155 patients, led by Associate Professor Michael Dickinson. Results of the trial have just published overnight in the New England Journal of Medicine.

Overall, and at a median follow-up a year (12.6 months) after Glofitamab treatment, 39% of the patients had a complete response. This was consistent (35% complete response rate) among 52 of these patients who had earlier received CAR T-cell therapy.

Associate Professor Dickinson said glofitamab‘s effects were also durable, as for many (78%) patients with a complete response this was ongoing for 12 months or more.

“We are greatly encouraged by these data which show a fixed course of glofitamab therapy can induce durable, complete responses for many patients who have faced disappointment from their disease not responding to multiple prior rounds of treatments, including CAR T-cell therapy,” says Associate Professor Dickinson, who is Lead of the Aggressive Lymphoma Disease Group within Clinical Haematology Department at Peter Mac and Royal Melbourne Hospital.

“Glofitamab is also exciting because it offers potential of an effective ‘off the shelf’ option for patients with hard-to-treat blood cancers and who live in parts of the world that may not have ready access to CAR T-cell therapy due to the complexity of delivering this highly tailored treatment.”

Australians with DLBCL who meet eligibility criteria may have funded access to CAR T-cell therapy – which involves collecting the patient’s T-cells, re-engineering these to fight their cancer, and infusing these back into the patient. About 40% of DLBCL patients achieve a durable remission after CAR T-cell therapy.

Glofitamab is a bispecific antibody treatment that engages the patient’s T-cells to fight their blood cancer. Patients receive a fixed course of intravenous infusions available “off-the-shelf” as opposed to CAR T-cell therapy which is uniquely prepared for each patient.

Read the paper titled “Glofitamab for Relapsed or Refractory Diffuse Large B-Cell Lymphoma”.

Associate Professor Dickinson is also leading a Peter-Mac sponsored Australian trial of glofitamab as part of front-line treatment for DLBCL that is recruiting at sites across Australia.

Note: Associate Professor Dickinson is currently in the US presenting at the 64th ASH Annual Meeting & Exposition and so availability for follow-up interviews may be limited 

Contacts

For more information contact the Peter Mac Communications team on 0417 123 048

About Peter Mac

Peter MacCallum Cancer Centre is a world-leading cancer research, education and treatment centre and Australia’s only public health service solely dedicated to caring for people affected by cancer.

  1. Collaboration with leading Canadian cancer centre commences with lecture from supportive and palliative care expert
  2. Young women with breast cancer can safely have a baby, study shows
  3. Six NHMRC Ideas Grants Awarded to Peter Mac Researchers for 2023
  4. New blood cancer research centre established with generous gift

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The Peter MacCallum Cancer Centre acknowledges the traditional owners of the land on which our five sites are located throughout Victoria. We recognise their strength and resilience and pay our respects to their Elders past and present.

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